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Synfacts 2006(1): 0042-0042
DOI: 10.1055/s-2005-921741
DOI: 10.1055/s-2005-921741
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
C1-Aminosulfoximines in Copper-Catalyzed Asymmetric Mukaiyama-Aldol Reactions
M. Langner, P. Rémy, C. Bolm*
RWTH Aachen, Germany
Further Information
Publication History
Publication Date:
16 December 2005 (online)
Significance
The Mukaiyama-aldol reaction is a very powerful method for the formation of β-hydroxy carbonyls. While reports of the asymmetric variant are known, the authors describe a nice system that has been optimized for a broad substrate scope to produce a variety of chiral tertiary alcohols. In addition to the Mukaiyama-aldol reaction, the authors report the synthesis of a variety of C1-symmetric aryl-bridged aminosulfoximines.