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Synfacts 2006(2): 0096-0096  
DOI: 10.1055/s-2005-921776
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-CP55,940

Contributor(s): Philip Kocienski, John Cooksey
N. Itagaki, T. Sugahara, Y. Iwabuchi*
Tohoku University, Japan
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Publikationsdatum:
23. Januar 2006 (online)

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Significance

The total synthesis of (-)-CP55,940 demonstrates the use of an asymmetric intramolecular aldol reaction/retro-aldol reaction strategy to install two of the three stereocenters present in the target molecule. The initial aldol adduct C is used as a temporary chiral scaffold to allow installation of these stereocenters using substrate control.