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Synfacts 2006(2): 0100-0100
DOI: 10.1055/s-2005-923600
DOI: 10.1055/s-2005-923600
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of (+)-Rollimembrin
G. Keum, C. H. Hwang, S. B. Kang, Y. Kim, E. Lee*
Seoul National University, Korea
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. Januar 2006 (online)
Significance
Rolliniastatin 1, Rollimembrin, and Membranacin are Annonaceous acetogenins isolated from Rollinia membranacea and Rollinia mucosa. They are in vitro inhibitors of the mitochondrial respiratory chain complex I. The dihydroxy bis-oxolane core of these natural products was constructed with high diastereoselectivity by two radical cyclization-Pummerer rearrangement-allylation sequences.