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Synfacts 2006(4): 0362-0362  
DOI: 10.1055/s-2006-932043
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Asymmetric Transfer Hydrogenation of Alkyl/Aryl and Dialkyl Ketones

Contributor(s): Mark Lautens, Andrew Martins
M. T. Reetz*, X. Li
Max-Planck Institut für Kohlenforschung, Mülheim/Ruhr, Germany
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Publikationsdatum:
24. März 2006 (online)

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Significance

Using a [RuCl2(p-cymene)]2/BINOL/xanthene-derived diphosphonite catalyst system, unprecedented enantioselectivity is demonstrated for the transfer hydrogenation of a variety of ketones. This catalyst system affords secondary chiral alcohols with excellent enantioselectivity for aryl/alkyl ketones, and previously unreported very good to excellent selectivity for dialkyl ketones.