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Synfacts 2006(6): 0582-0582  
DOI: 10.1055/s-2006-934460
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Catalytic Enantioselective Hydrogenation of Quinolines and Isoquinolines

Contributor(s): Mark Lautens, Yann Béthuel
S.-M. Lu, Y.-Q. Wang, X.-W. Han, Y.-G. Zhou*
Dalian Institute of Sciences, P. R. of China
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Publication History

Publication Date:
19 May 2006 (online)

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Significance

Tetrahydroquinolines and dihydro­isoquinolines are important building blocks found in a wide variety of biologically relevant alkaloids. The authors describe their access via an efficient catalytic, enantioselective hydrogenation where the nitrogen needs to be activated as an acylammonium species with a chloroformate prior to hydrogenation.