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Synfacts 2006(6): 0588-0588  
DOI: 10.1055/s-2006-934463
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

A New Lipase/Vanadium Combination for DKR of Allyl Alcohols

Contributor(s): Mark Lautens, Yann Béthuel, Benjamin List, Sebastian Hoffmann
S. Akai*, K. Tanimoto, Y. Kanao, M. Egi, T. Yamamoto, Y. Kita*
University of Shizuoka and Osaka University, Japan
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Publikationsdatum:
19. Mai 2006 (online)

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Significance

The synthesis of diverse allylic acetates has been achieved by dynamic kinetic resolution (DKR) using a combination of two catalysts: ­lipase for resolution and vanadium for racemization. Very good yields (up to 96%) and enantioselectivities (up to 99%) could be reached using this convenient methodology.