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Synfacts 2006(6): 0536-0536  
DOI: 10.1055/s-2006-934495
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of UCS1025A

Contributor(s): Philip Kocienski, John Cooksey
T. H. Lambert, S. J. Danishefsky*
Columbia University, New York, USA
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Publication History

Publication Date:
19 May 2006 (online)

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Significance

UCS1025A is an anti-proliferative agent isolated from the fermentation broth of the Acremonium sp. KY4917 fungus. The Danishefsky group reports a concise total synthesis of UCS1025A which utilizes a diastereoselective cyclization of a C 2-symmetric imide and Reformatsky-type fragment linkage as the key steps in the synthesis.