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Synfacts 2006(7): 0717-0717
DOI: 10.1055/s-2006-941890
DOI: 10.1055/s-2006-941890
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Rh-Catalyzed Asymmetric Arylation ofN-Sulfamoyl Aldimines
R. B. Jagt, P. Y. Toullec, D. Geerdink, J. G. de Vries*, B. L. Feringa*, A. J. Minnaard*
University of Groningen, The Netherlands
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. Juni 2006 (online)
Significance
Enantioselective synthesis of diarylmethylamines is quite important for the pharmaceutical industry, as this unit is widespread in modern drug structures. Addition of arylboronic acids to imines is a highly attractive way of their synthesis, as many arylboronic acids are stable, commercially available products. This method possesses important advantages over the previously known procedure: use of readily available ligand, low loading of the catalyst, only little required excess of the boronic acids.