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Synfacts 2006(7): 0717-0717
DOI: 10.1055/s-2006-941890
DOI: 10.1055/s-2006-941890
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Rh-Catalyzed Asymmetric Arylation ofN-Sulfamoyl Aldimines
R. B. Jagt, P. Y. Toullec, D. Geerdink, J. G. de Vries*, B. L. Feringa*, A. J. Minnaard*
University of Groningen, The Netherlands
Further Information
Publication History
Publication Date:
22 June 2006 (online)
![](https://www.thieme-connect.de/media/synfacts/200607/lookinside/thumbnails/10.1055-s-2006-941890-1.jpg)
Significance
Enantioselective synthesis of diarylmethylamines is quite important for the pharmaceutical industry, as this unit is widespread in modern drug structures. Addition of arylboronic acids to imines is a highly attractive way of their synthesis, as many arylboronic acids are stable, commercially available products. This method possesses important advantages over the previously known procedure: use of readily available ligand, low loading of the catalyst, only little required excess of the boronic acids.