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Synfacts 2006(11): 1091-1091  
DOI: 10.1055/s-2006-949393
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (+)-β-Erythroidine

Contributor(s): Philip Kocienski, Fiona Black
H. Fukumoto, K. Takahashi, J. Ishihara, S. Hatakeyama*
Nagasaki University, Japan
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Publication History

Publication Date:
24 October 2006 (online)

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Significance

(+)-β-Erythroidine is a non-aromatic dienoid-type Erythrina alkaloid. The first total synthesis of (+)-β-erythroidine is reported wherein the quaternary stereocenter is installed using a Lewis acid catalyzed cyclization and the erythrinan skeleton is constructed via ring-closing metathesis of a dienyne.