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Synfacts 2006(11): 1128-1128  
DOI: 10.1055/s-2006-949433
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Cu-Catalyzed Asymmetric SN2′ Reaction onβ-Disubstituted Allylic Chlorides

Contributor(s): Mark Lautens, Yann Béthuel
C. A. Falciola, K. Tissot-Croset, A. Alexakis*
University of Geneva, Switzerland
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Publikationsdatum:
24. Oktober 2006 (online)

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Significance

In the present article, the authors expand the scope of their previously developed Cu-catalyzed asymmetric SN2′ reaction with Grignard nucleophiles (Angew. Chem. Int. Ed. 2004, 43, 2426-2428) to more highly substituted β-di­substituted allylic halides.