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Synfacts 2006(11): 1173-1173  
DOI: 10.1055/s-2006-949460
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart · New York

Phase-Transfer-Catalyzed Asymmetric Alkylation of α-Acyl-γ-butyrolactones

Contributor(s): Benjamin List, Subhas Chandra Pan
T. Ooi, T. Miki, K. Fukumoto, K. Maruoka*
Kyoto University, Japan
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Publication History

Publication Date:
24 October 2006 (online)

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Significance

Here the authors report a phase-transfer-catalyzed asymmetric alkylation of α-acyl-γ-butyrolactones under mild conditions. Catalyst 1 in combination with Cs2CO3 has been found to be effective for this reaction. With 1 mol% of the catalyst good to high yields (40-94%) and enantio­selectivities (er = 78:22 to >99:1) are obtained for different α-acyl-γ-butyrolactones with different benzylic and allylic halides.