Mn-Mediated Radical Diastereoselective Alkylation of N-Acylhydrazones

Significance

Enantioselective radical addition to imines represents a mild useful method for the asymmetric amine synthesis. The authors developed an elegant, versatile protocol for the Mn-carbonyl-promoted diastereoselective addition of primary and secondary alkyl radicals to chiral hydrazones. This method allows a simple enantio­selective preparation of functionalized amines and hydrazines with a chiral center at the α-carbon. The procedure is relatively simple, good yields and very high diastereoselectivities are achieved in most cases.