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Synfacts 2007(1): 0003-0003  
DOI: 10.1055/s-2006-955656
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (±)-β-Erythroidine

Contributor(s): Philip Kocienski, Fiona Black
Y. He, R. L. Funk*
Pennsylvania State University, University Park, USA
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Publication History

Publication Date:
15 December 2006 (online)

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Significance

A 13-step synthesis of the erythrinan alkaloid (±)-β-erythroidine is reported. A Diels-Alder cycloadditon, an intramolecular Heck cyclization and an electrocyclic ring closure are employed in the construction of the tetracyclic ring system.