Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2007(1): 0091-0091
DOI: 10.1055/s-2006-955662
DOI: 10.1055/s-2006-955662
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart · New York
Nonenzymatic Kinetic Resolution of Indolines
F. O. Arp, G. C. Fu*
Massachusetts Institute of Technology, Cambridge, USA
Further Information
Publication History
Publication Date:
15 December 2006 (online)
Significance
The first kinetic resolution of 2-substituted indolines 1 through catalytic N-acylation is described. The planar chiral pyridine derivative 4 functions as a Lewis basic catalyst, leading to the resolved indolines 2 in very good enantioselectivities (up to er = 99:1) after 51-65% conversion. Notably, 2,3-disubstituted indolines are also suitable substrates and substituents in the 5-position are tolerated.