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Synfacts 2007(1): 0060-0060  
DOI: 10.1055/s-2006-955734
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Role of the X Anion in the VO(salen) (X)-Mediated Cyanohydrin Synthesis

Contributor(s): Mark Lautens, Yann Béthuel
Y. N. Belokon*, V. I. Maleev, M. North*, D. L. Usanov
Institute of Organo-Element Compounds, Russian Academy of Sciences, Russian Federation and University of Newcastle, UK
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Publikationsdatum:
15. Dezember 2006 (online)

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Significance

Chiral cyanohydrins are important building blocks used as intermediates towards natural products synthesis or parts of biologically active molecules. In the present paper, the authors optimize their recently developed vanadium(salen) complex to combine both excellent catalytic activity and enantioselectivity.