Synthesis of Cytostatin

B. G. Lawhorn; S. B. Boga; S. E. Wolkenberg; D. A. Colby; C.-M. Gauss; M. R. Swingle; L. Amable; R. E. Honkanen; D. L. Boger

doi:10.1055/s-2007-968390

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Synfacts 2007(5): 0456-0456
DOI: 10.1055/s-2007-968390

Synthesis of Natural Products and Potential Drugs

Synthesis of Cytostatin

Contributor(s): Philip Kocienski, Fiona Black
B. G. Lawhorn, S. B. Boga, S. E. Wolkenberg, D. A. Colby, C.-M. Gauss, M. R. Swingle, L. Amable, R. E. Honkanen, D. L. Boger*
The Scripps Research Institute, La Jolla and University of South Alabama College of Medicine, Mobile, USA

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Publikationsverlauf

Publikationsdatum:
24. April 2007 (online)

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Significance

A convergent synthesis of cytostatin and its C10 and C11 stereoisomers is reported which confirms the relative and absolute stereochemistry of this cytotoxic natural product. Several cytostatin analogues are also synthesized for biological evaluation.