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Synfacts 2007(11): 1126-1126  
DOI: 10.1055/s-2007-991203
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Psymberin

Contributor(s): Philip Kocienski, Indu Dager
X. Huang*, N. Shao, A. Palani, R. Aslanian, A. Buevich
Schering-Plough Research Institute, Kenilworth, USA
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Publication History

Publication Date:
23 October 2007 (online)

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Significance

Psymberin, a member of the pederin family, is a potent and selective cytotoxin derived from a sponge Psammocinia sp. A PhI(OAc)2-mediated oxidative cyclization reaction of N-acyl enamine D to form α-oxy N-acyl aminal E is the key step in the synthesis (Tetrahedron Lett. 2007, 48, 1967).