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Synfacts 2007(11): 1122-1122  
DOI: 10.1055/s-2007-991209
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Chlorofusin

Contributor(s): Philip Kocienski
W.-J. Qian, W.-G. Wei, Y.-X. Zhang, Z.-J. Yao*
Shanghai Institute of Organic Chemistry, P. R. of China
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Publication History

Publication Date:
23 October 2007 (online)

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Significance

The phosphoprotein p53 and the oncogene product MDM2 form a complex that blocks the DNA-bonding domain of p53, thereby preventing it from activating transcription of the genes required for induction of G1 arrest or apoptosis. Chlorofusin is a metabolite of Microdochium caespitosum that antagonizes the interaction between p53 and MDM2, making it a potential lead for cancer treatment.