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Synfacts 2007(11): 1127-1127
DOI: 10.1055/s-2007-991210
DOI: 10.1055/s-2007-991210
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Total Synthesis of Biyouyanagin A
K. C. Nicolaou*, D. Sarlah, D. M. Shaw
The Scripps Research Institute and University of California, San Diego, La Jolla, USA
Further Information
Publication History
Publication Date:
23 October 2007 (online)
Significance
Biyouyanagin A is isolated from Hypericum chinense L. var. salicifolium, a plant used as a folk medicine in Japan. It selectively inhibits the HIV replication in H9 lymphocytes and has got a therapeutic index of greater than 31.3. A 12-step total synthesis of biyouyanagin A with the revised stereochemistry at C17, C18, and C24 is reported here.