RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
Synfacts 2007(11): 1115-1115
DOI: 10.1055/s-2007-991212
DOI: 10.1055/s-2007-991212
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of (+)-Asperazine
S. P. Govek, L. E. Overman*
University of California, Irvine, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. Oktober 2007 (online)
Significance
Asperazine was isolated from a salt-water culture of Aspergillus niger. Its putative anticancer activity was disproved by the synthesis depicted, which features a Stille coupling followed by an intramolecular Heck cyclization to install the highly congested quaternary center in B.