Suzuki Cross-Coupling Reaction Between Unactivated Alkyl Halides and Alkyl Borates

B. Saito; G. C. Fu

doi:10.1055/s-2007-991230

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Synfacts 2007(11): 1202-1202
DOI: 10.1055/s-2007-991230

Metal-Mediated Synthesis

Suzuki Cross-Coupling Reaction Between Unactivated Alkyl Halides and Alkyl Borates

Contributor(s): Paul Knochel, Tobias Thaler
B. Saito, G. C. Fu*
Massachusetts Institute of Technology, Cambridge, USA

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Publication History

Publication Date:
23 October 2007 (online)

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Significance

This work represents a valuable achievement in the field of sp³-sp³ cross-coupling reactions. It is the first example of a Suzuki cross-coupling reaction between unactivated secondary alkyl halides and primary alkyl borates. The stereoinformation of the respective secondary alkyl bromides is not retained in this reaction.