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Synfacts 2007(11): 1188-1188  
DOI: 10.1055/s-2007-991253
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Enantioselective Synthesis of α-Chiral Aminooxazoles

Contributor(s): Mark Lautens, Michael Langer
S.-X. Wang, M.-X. Wang, D.-X. Wang, J. Zhu*
Institute of Chemistry, Chinese Academy of Sciences, Beijing, P. R. of China and Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France
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Publikationsdatum:
23. Oktober 2007 (online)

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Significance

The enantioselective addition of isonitriles to activated carbonyls remains challenging despite many nonchiral examples in Passerini or Ugi multicomponent reactions. The Al(salen) complex catalyzes the enantioselective addition of isocyanides to aldehydes and affords substituted α-chiral aminooxazoles in good yields and moderate to good enantioselectivities.