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Synfacts 2007(11): 1174-1174  
DOI: 10.1055/s-2007-991266
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Tandem Catalysis: Sequential Hydroformylation-Aldol Reactions

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
S. Chercheja, P. Eilbracht*
Universität Dortmund, Germany
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Publication History

Publication Date:
23 October 2007 (online)

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Significance

This report describes an excellent tandem metal-organo-catalysis reaction that generates products with moderate ee values. The authors employ the widely used industrial hydroformylation reaction in combination with the proline-catalyzed direct aldol reaction to generate β-hydroxy ketones. Many catalysts, ligands, CO pressures, and H2 pressures were screened to optimize this reaction.