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Synfacts 2007(12): 1294-1294  
DOI: 10.1055/s-2007-991345
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Use of Fluorinated Alcohols in Enantioselective Hydrogenation

Contributor(s): Hisashi Yamamoto, Marina Naodovic
N. V. Dubrovina*, I. A. Shuklov, M.-N. Birkholz, D. Michalik, R. Paciello, A. Börner
Leibniz-Institut für Katalyse an der Universität Rostock e. V., Institut für Chemie der Universität Rostock and BASF AG, Ludwigshafen, Germany
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Publikationsdatum:
22. November 2007 (online)

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Significance

Self-assembling phosphanyl-pyridone ligands have been used in several hydro­genation reactions. Difficulties obtaining both good yields and selectivities are still present. In this report, those difficulties are eliminated by use of fluorinated alcohols which enable formation of hydrogen bonding between ligand molecules - the key feature responsible for the stereoselective outcome of the reaction.