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Synfacts 2008(5): 0523-0523  
DOI: 10.1055/s-2008-1072523
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Oxazolones via Copper(II)- and Gold(I)-Catalyzed Transformations

Contributor(s): Paul Knochel, Andrei Gavryushin
F. M. Istrate, A. K. Buzas, I. D. Jurberg, Y. Odabachian, F. Gagosz*
Ecole Polytechnique, Palaiseau, France
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Publication History

Publication Date:
23 April 2008 (online)

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Significance

The authors reported a simple two-step sequence for the preparation of various 1,5-disubstituted oxazolones, starting from 1-bromo­alkynes and N-substituted carbamates. The method has an advantage of simplicity and employs rather mild conditions, affording a broad range of substituted oxazolones. The products are useful intermediates in synthesis and may possess various biological activities.