Suzuki-Miyaura Coupling Reaction Using Palladium Nanoparticles Immobilized on SPB

Significance

Palladium nanoparticles immobilized on spherical polyelectrolyte brushes (Pd@SPB) were synthesized and found to promote the Suzuki-Miyaura cross-coupling reaction. Thus, the spherical polyelectrolyte brushes having the (2-methylpropenyloxyethyl)trimethylammonium cation were prepared according to the reported procedures (Y. Mei, G. Sharma, Y. Lu, M. Ball­auff Langmuir 2005, 21, 12229). The reaction of SPB with Na₂PdCl₄ followed by reduction with NaBH₄ gave the palladium nanoparticles immobilized in the SPB matrix (Pd@SPB). The Suzuki-Miyaura coupling reaction of aryl halides with phen­ylboronic acid was carried out in the presence of Pd@SPB (0.09 mol% Pd) in H₂O-THF to give the corresponding biphenyls in good yield (14 examples, 50-94% yield).