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Synfacts 2008(5): 0491-0491  
DOI: 10.1055/s-2008-1072668
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Nickel-Catalyzed Cross-Coupling of Benzyl Bromides and Trialkynylindium Reagents

Contributor(s): Mark Lautens, Valentina Aureggi
J. Caeiro, J. P. Sestelo*, L. A. Sarandeses*
Universidade da Coruña, Spain
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Publikationsdatum:
23. April 2008 (online)

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Significance

The development of a new efficient enantioselective nickel-catalyzed sp-sp3 cross-coupling reaction between alkynylindium reagents and racemic secondary benzyl bromides is reported. The corresponding products are obtained in moderate to good yields and enantioselectivities using a commercially available catalytic system.