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Synfacts 2008(5): 0451-0451  
DOI: 10.1055/s-2008-1072710
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Shimalactone A

Contributor(s): Philip Kocienski, Arndt W. Schmidt
V. Sofiyev, G. Navarro, D. Trauner*
University of California, Berkeley, USA
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Publikationsverlauf

Publikationsdatum:
23. April 2008 (online)

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Significance

The bicyclo[4.2.0]octane skeleton, found in several polyketide natural products, is believed to be formed by a sequence of electro­cyclizations. By synthesis of a suitable precursor and demonstrating that the spontaneous cyclization leads to the desired compounds, further support for the biosynthetic proposal has been gained.