PDF herunterladen
Synfacts 2008(7): 0746-0746  
DOI: 10.1055/s-2008-1077830
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Isoquinolone Synthesis via Decarbonylative Addition of Phthalimides to Alkynes

Contributor(s): Paul Knochel, Tobias Thaler
Y. Kajita, S. Matsubara*, T. Kurahashi*
Kyoto University, Japan
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
20. Juni 2008 (online)

    Lizenzen und Reprints

Significance

A novel synthetic access to iso­quinolones via a Ni(0)-catalyzed decarbonylative addition of alkynes to phthalimides has been developed. This reaction shows that activated C-N bonds can undergo a decarbonylative Ni(0)-complex insertion enabling an intermolecular addition to alkynes.