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Synfacts 2008(7): 0745-0745  
DOI: 10.1055/s-2008-1077833
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

FeCl2-Catalyzed Amidation of C-H Bonds with N-Bromosuccinimide as Oxidizing Agent

Contributor(s): Paul Knochel, Tobias Thaler
Z. Wang, Y. Zhang, H. Fu*, Y. Jiang, Y. Zhao
Tsinghua University, Beijing and Tsinghua University, Shenzhen, P. R. of China
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Publikationsverlauf

Publikationsdatum:
20. Juni 2008 (online)

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Significance

A novel FeCl2-catalyzed C-N bond formation via benzylic C-H bond activation has been disclosed. The reaction was applied to diphenylmethane, substituted and non-substituted ethylbenzenes. A number of functional groups were tolerated. The reaction proceeds in air between 50-80 °C. The activity order of the benzylic reagents was found to be diphenylmethane > ethylbenzene > 4-bromoethylbenzene.