Suzuki-Miyaura Cross-Coupling of Trifluoroboratohomoenolates

Significance

The application of the corresponding alkyltrifluoroborates as nucleophiles in a cross-coupling reaction with aryl and alkenyl halides or triflates allowed a simple preparation of various 2-arylethyl ketones, amides and esters. The method tolerates a broad variety of functional groups, and, due to its simplicity and excellent versatility, can be very useful in combinatorial synthesis and creation of compound libraries.