Vinylation and Difluorovinylation of Arylboronic Acids with Vinyl Tosylates

Significance

Substituted styrenes are valuable intermediates in organic synthesis as well as useful polymer precursors. This publication describes a useful alternative to common methods for their synthesis based on olefinic moieties as nucleophilic species. Vinyl and 2,2-difluorovinyl tosylates are easily to prepare and to handle. The cross-coupling reactions proceed in good yields even with highly functionalized heterocyclic substrates. Difluorostyrenes are interesting bioisosteres of carbonyl compounds.