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Synfacts 2008(7): 0725-0725  
DOI: 10.1055/s-2008-1077846
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Tandem Enantioselective Conjugate Addition-Mannich Reactions

Contributor(s): Hisashi Yamamoto, Joshua P. Abell
J. C. González-Gómez, F. Foubelo*, M. Yus*
Universidad de Alicante, Spain
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Publication History

Publication Date:
20 June 2008 (online)

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Significance

This diastereoselective synthesis provides a convenient route to chiral β-amino ketones derived from chiral N-sulfinimines. A single isomer was obtained demonstrating the potential utility of this catalytic system. Various alkylzinc reagents as well as Michael acceptors were utilized. Also described is the flexibility to generate both isomers of the amino moiety.