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Synfacts 2008(10): 1011-1011  
DOI: 10.1055/s-2008-1078285
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Clavosolide D

Contributor(s): Philip Kocienski, Indu Dager
P. T. Seden, J. P. H. Charmant, C. L. Willis*
University of Bristol, UK
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Publikationsdatum:
22. September 2008 (online)

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Significance

The first total synthesis of (-)-clavosolide D features a stereoselective Prins cyclization and Nicolaou NBS glycosidation protocol to construct both tetrahydrofuran fragments G and H.