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Synfacts 2008(10): 1019-1019  
DOI: 10.1055/s-2008-1078287
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of GE2270 A

Contributor(s): Philip Kocienski
O. Delgado, H. M. Müller, T. Bach*
Technische Universität München, Garching, Germany
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Publikationsdatum:
22. September 2008 (online)

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Significance

G2270A is a thiopeptide antibiotic isolated from Planobispora rosea that inhibits bacterial elongation factor Tu, an ubiquitous essential enzyme for protein biosynthesis. A markworthy feature is the use of three Pd(0)-catalyzed coupling reactions to apend three thiazole rings to 2,6-dibromo-3-iodopyridine.