Transfer Hydrogenation of Allylic Alcohols Using Ru(OH)x/Al2O3

doi:10.1055/s-2008-1078439

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Synfacts 2008(7): 0773-0773
DOI: 10.1055/s-2008-1078439

Polymer-Supported Synthesis

Transfer Hydrogenation of Allylic Alcohols Using Ru(OH)_x/Al₂O₃

Contributor(s): Yasuhiro Uozumi, Toshimasa Suzuka
J. W. Kim, T. Koike, M. Kotani, K. Yamaguchi, N. Mizuno*
The University of Tokyo and Japan Science and Technology Agency, Saitama, Japan

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Publication History

Publication Date:
20 June 2008 (online)

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Significance

Ruthenium hydroxide supported on alumina (Ru(OH)_x/Al₂O₃) was found to promote the transfer hydrogenation of allylic alcohols to saturated alcohols without any additive. Thus, the Ru(OH)_x/Al₂O₃ catalyst was prepared from ruthenium(III) chloride, γ-Al₂O₃, and NaOH according to reported procedures (K. Yamaguchi, N. Mizuno Angew. Chem. Int. Ed. 2002, 41, 4538). The transfer hydrogenation of 1-octen-3-ol with isopropyl alcohol was carried out in the presence of 2 mol% of Ru(OH)_x/Al₂O₃ to give 3-octanol in 94% yield. The Ru(OH)_x/Al₂O₃ catalyst was recovered and reused three times without any loss of catalytic activity (95% yield for three times).