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Synfacts 2008(7): 0767-0767  
DOI: 10.1055/s-2008-1078440
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Selective Reduction of the Nitro Group Using Nanocyrstalline MgO-Stabilized Palladium(0)

Contributor(s): Yasuhiro Uozumi, Toshimasa Suzuka
M. L. Kantam*, R. Chakravarti, U. Pal, B. Sreedhar, S. Bhargava
Indian Institute of Chemical Technology, Hyderabad, India and RMIT University, Melbourne, Australia
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Publication History

Publication Date:
20 June 2008 (online)

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Significance

Nanocrystalline magnesium oxide-stabilized palladium(0) [NAP-Mg-Pd(0)] was found to promote the reduction of the nitro group to amine. Thus, NAP-Mg-PdCl2 was obtained from the reaction of nanocrystalline MgO with Na2PdCl4 in water and reduced with H2NNH2H2O to give NAP-Mg-Pd(0). Reduction of nitrobenzene with H2 was carried out in the presence of NAP-Mg-Pd(0) to give the aniline in 98% yield. The NAP-Mg-Pd(0) was recovered and reused five times without any loss of catalytic activity (98% yield for five times).