Download PDF
Synfacts 2008(7): 0778-0778  
DOI: 10.1055/s-2008-1078442
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Heteropoly Acid Catalyzed Hydroamination of Alkenes

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Chung Keun Jin
L. Yang, L.-W. Xu*, C.-G. Xia*
Lanzhou Institute of Chemical Physics, P. R. of China and National University of Singapore, Singapore
Further Information

Publication History

Publication Date:
20 June 2008 (online)

   Permissions and Reprints

Significance

Heteropoly acids (HPAs) catalyzed hydroamination of alkenes was described. Thus, the intermolecular hydroamination of alkenes (2 mol equiv) with amides or carbamates was performed in the presence of H4SiW12O40nH2O (3 mol%) in dichloroethane (DCE) at r.t. to 85 °C to afford the corresponding products 1-14 in 48-91% isolated yield. The catalyst was reused twice with slight loss of catalytic activity (1st use = 78%, 2nd use = 74%, 3rd use = 62%).