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Synlett 2023; 34(07): 807-814
DOI: 10.1055/a-1903-5174
DOI: 10.1055/a-1903-5174
cluster
Chemical Synthesis and Catalysis in India
Metal- and Solvent-Free Synthesis of m-Terphenyls by an Iodine-Catalyzed Tandem Formal [3+3]-Cycloaddition/Oxidation
Financial support from the Science and Engineering Research Board (SERB) through the award of a research grant (CRG/2021/006424) is gratefully acknowledged.
Abstract
A tandem formal [3+3]-cycloaddition/oxidation between chalcones and β-enamine esters, employing iodine as a catalyst, was developed for the construction of various substituted m-terphenyls. A wide range of chalcones and β-enamine esters were tested under metal- and solvent-free conditions for the synthesis of substituted m-terphenyls in good to excellent yields in the presence of sulfur as an oxidant. This reaction proceeds with the formation of four new bonds and one new ring, with a high atom economy.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1903-5174.
- Supporting Information
Publication History
Received: 13 May 2022
Accepted after revision: 19 July 2022
Accepted Manuscript online:
19 July 2022
Article published online:
11 August 2022
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