Purine-Based AIEgens with Different Morpholine Substitution Sites and Their Application in Lipophagy Imaging

Lei Shi; Ai-Wen Yu; Wei-Han Meng; Kun-Peng Xie; Kun Li

doi:10.1055/a-2201-3612

Synlett, Table of Contents

Synlett 2024; 35(01): 135-139
DOI: 10.1055/a-2201-3612

cluster

Functional Dyes

Purine-Based AIEgens with Different Morpholine Substitution Sites and Their Application in Lipophagy Imaging

Lei Shi

^aKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, Sichuan, P. R. of China

^bState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610064, Sichuan, P. R. of China

,

Ai-Wen Yu

^aKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, Sichuan, P. R. of China

,

Wei-Han Meng

^aKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, Sichuan, P. R. of China

,

Kun-Peng Xie

^aKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, Sichuan, P. R. of China

,

Kun Li∗

^aKey Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, Sichuan, P. R. of China

› Author Affiliations

Abstract

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Abstract

Lysosomes are an important organelle involved in many physiological processes. However, enhancing the accurate localization of lysosomes by chemical modification is still a problem. Herein, the purine-based AIEgens with different morpholine substitution sites were constructed. The effects of modification sites on the absorption, fluorescence, pH, viscosity and bioimaging properties of the probes were systematically studied. The morpholine modification at the phenyl site could effectively enhance the fluorescence behavior and the lysosome specificity. The morpholine-modified AIEgens could achieve the further lysosome imaging during the lipophagy process. This basic study might do favor to design more probes for further lysosome function studies.

Key words

purine - aggregation-induced emission - lipophagy - morpholine - lysosome-targeting - fluorescent probe

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References

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