The Development of Radical/Palladium Relay Catalysis for C–H Carbonylation

Yongzheng Ding; Hanmin Huang

doi:10.1055/a-2413-0458

Synlett, Table of Contents

Synlett 2025; 36(07): 749-754
DOI: 10.1055/a-2413-0458

synpacts

The Development of Radical/Palladium Relay Catalysis for C–H Carbonylation

Yongzheng Ding

^aHefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, 230026, P. R. of China

,

Hanmin Huang∗

^aHefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, 230026, P. R. of China

^bKey Laboratory of Precision and Intelligent Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, P. R. of China

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Abstract

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Abstract

The radical/palladium relay catalysis for C–H bond carbonylation is an attractive research topic in synthetic chemistry. It can rapidly prepare carbonylated molecules for synthetic or pharmaceutical applications from highly sought-after feedstocks, such as alkylarenes, alkanes, alkenes, or ethers. The main objective of this Synpacts article is to summarize the development of this research area, mainly focusing on radical/palladium relay catalysis for the carbonylation of single and double C–H bonds.

1 Introduction

2 Radical/Palladium Relay Catalysis for Single C–H Bond Carbonylation Reaction

3 Radical/Palladium Relay Catalysis for Double C–H Bond Carbonylation Reaction

4 Conclusions

Key words

relay catalysis - C–H bond activation - carbonylation - selectivity - hydrogen atom abstraction

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References

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