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Synlett 2025; 36(07): 749-754
DOI: 10.1055/a-2413-0458
DOI: 10.1055/a-2413-0458
synpacts
The Development of Radical/Palladium Relay Catalysis for C–H Carbonylation
We are grateful for financial support from the National Key Research and Development Program of China (2023YFA1507500), the National Natural Science Foundation of China (21925111, 22350008, and 22301289), and the Strategic Priority Research Program of Chinese Academy of Sciences (XDB0450301).
Abstract
The radical/palladium relay catalysis for C–H bond carbonylation is an attractive research topic in synthetic chemistry. It can rapidly prepare carbonylated molecules for synthetic or pharmaceutical applications from highly sought-after feedstocks, such as alkylarenes, alkanes, alkenes, or ethers. The main objective of this Synpacts article is to summarize the development of this research area, mainly focusing on radical/palladium relay catalysis for the carbonylation of single and double C–H bonds.
1 Introduction
2 Radical/Palladium Relay Catalysis for Single C–H Bond Carbonylation Reaction
3 Radical/Palladium Relay Catalysis for Double C–H Bond Carbonylation Reaction
4 Conclusions
Key words
relay catalysis - C–H bond activation - carbonylation - selectivity - hydrogen atom abstractionPublication History
Received: 04 August 2024
Accepted after revision: 10 September 2024
Accepted Manuscript online:
10 September 2024
Article published online:
08 October 2024
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