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Synfacts 2025; 21(02): 131
DOI: 10.1055/a-2496-9349
DOI: 10.1055/a-2496-9349
Synthesis of Materials and Unnatural Products
Synthesis and Trapping of an Anti-Bredt Olefin
McDermott L,
Walters ZG,
French SA,
Clark AM,
Ding J,
Kelleghan AV,
Houk KN,
Garg NK *.
University of California, Los Angeles, USA
A Solution to the Anti-Bredt Olefin Synthesis Problem.
Science 2024;
386: eadq3519
DOI: 10.1126/science.adq3519
A Solution to the Anti-Bredt Olefin Synthesis Problem.
Science 2024;
386: eadq3519
DOI: 10.1126/science.adq3519
Keywords
anti-Bredt olefin - syn-elimination - bridgehead carbon - strained carbon–carbon double bond
Significance
The synthesis of a representative anti-Bredt olefin, which refers to the geometrically distorted alkene with the double bond constituted a bridgehead carbon, is accomplished.
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Comment
The study also illustrates the high reactivity of such a strained anti-Bredt olefin, which undergoes cycloaddition with various trapping agents, showing high to decent regio- and stereoselectivity.
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Publikationsverlauf
Artikel online veröffentlicht:
28. Januar 2025
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