Download PDF
Synfacts 2025; 21(02): 131
DOI: 10.1055/a-2496-9349
Synthesis of Materials and Unnatural Products

Synthesis and Trapping of an Anti-Bredt Olefin

Contributor(s):
Dahui Zhao
,
Wenyue Zhong
McDermott L, Walters ZG, French SA, Clark AM, Ding J, Kelleghan AV, Houk KN, Garg NK *. University of California, Los Angeles, USA
A Solution to the Anti-Bredt Olefin Synthesis Problem.

Science 2024;
386: eadq3519
CrossrefPubMedSearch in Google Scholar
› Further Information
 
 PDF Download Permissions and Reprints

Keywords

anti-Bredt olefin - syn-elimination - bridgehead carbon - strained carbon–carbon double bond

Significance

The synthesis of a representative anti-Bredt olefin, which refers to the geometrically distorted alkene with the double bond constituted a bridgehead carbon, is accomplished.


#

Comment

The study also illustrates the high reactivity of such a strained anti-Bredt olefin, which undergoes cycloaddition with various trapping agents, showing high to decent regio- and stereoselectivity.


#
#

Publication History

Article published online:
28 January 2025

© 2025. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany


   Permissions and Reprints