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Synthesis 2025; 57(07): 1306-1312
DOI: 10.1055/a-2508-3790
DOI: 10.1055/a-2508-3790
psp
Nickel(II)-Catalyzed Cycloisomerization of 1,6-Dienes
This work was supported by the National Natural Science Foundation of China (22401070), Anhui Postdoctoral Science Foundation (2023B666), and the Fundamental Research Funds for the Central Universities of China (PA2024GDSK0102).
Abstract
A nickel-catalyzed protocol for the cycloisomerization of 1,6-dienes has been developed. Using commercially available NiBr₂ and PPh₃ as catalysts, Zn as a reductant, and ZnI₂ as an additive, the methodology efficiently converts various 1,6-dienes into pyrrolidine derivatives in excellent yields and high selectivity.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2508-3790.
- Supporting Information
Publikationsverlauf
Eingereicht: 02. Dezember 2024
Angenommen nach Revision: 26. Dezember 2024
Accepted Manuscript online:
03. Januar 2025
Artikel online veröffentlicht:
20. Februar 2025
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