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DOI: 10.1055/a-2510-0519
Light-Induced Metal-Free Catalyzed C–H Alkylation of (Iso)Quinolines
We are grateful for the financial support of the Key Research and Development Program of Zhejiang Province (Grant No. 2022C03016).
Abstract
A new method for preparing alkylated (iso)quinolines with substituted (iso)quinolines and alkanes as substrates, PIFA as an oxidant, and Rose bengal as a photosensitizer under 50 W light irradiation is proposed. Diverse structures were shown to be tolerated under optimal conditions, and a series of alkylated products were obtained in the desired yields. Compared with previous reactions using aldehydes and carboxylic acids as carbon sources, this method uses simple alkanes as carbon sources, offering good chemical stability and high atom economy.
Key words
(iso)quinolines - cycloalkanes/straight alkanes - visible light - alkylation - Rose bengalSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2510-0519.
- Supporting Information
Publication History
Received: 01 November 2024
Accepted after revision: 03 January 2025
Accepted Manuscript online:
03 January 2025
Article published online:
21 February 2025
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