PDF herunterladen
Synfacts 2025; 21(03): 328
DOI: 10.1055/a-2518-2534
Peptide Chemistry

PTC-Catalyzed Asymmetric Alkylation of Glycine Imines for the Synthesis of Unnatural Amino Acid Esters

Rezensent(en):
Hisashi Yamamoto
,
Isai Ramakrishna 
Lygo B, Allbutt B *. University of Nottingham, UK
Asymmetric PTC Alkylation of Glycine Imines: Variation of the Imine Ester Moiety.

Synlett 2004; 326-328
Thieme ConnectSuche in Google Scholar
› Weitere Informationen
 
 als PDF herunterladen Lizenzen und Reprints

Keywords

asymmetric alkylation - glycine imines - alkyl bromides - unnatural amino esters

Significance

Asymmetric alkylation is a powerful tool in organic synthesis to synthesize optically active molecules. In 2004, Lygo et.al developed a quaternary-ammonium-derived phase-transfer-catalyst-catalyzed asymmetric alkylation of glycine imines for the synthesis of unnatural amino acid esters.


#

Comment

A series of unnatural amino acid esters were synthesized by asymmetric phase-transfer alkylation of various glycine imine esters. This reaction proceeded smoothly to deliver the desired products in good yields and with excellent optical purities.


#
#

Publikationsverlauf

Artikel online veröffentlicht:
25. Februar 2025

© 2025. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany


   Lizenzen und Reprints