DOI: 10.1055/s-00000131

Synfacts

Issue 03 · Volume 21 · March 2025 DOI: 10.1055/s-015-61120

Synthesis of Natural Products

z221
All PDFs of this category
221
Total Synthesis of (–)-Scabrolide B
222
Total Synthesis of (+)-Kalmanol
223
Total Synthesis of (+)-Hyperbeanol A
224
Total Synthesis of (+)-Euphorbialoid A
225
Total Synthesis of (−)-Macrocalin B
226
Synthesis of (+)-Mannolide B
227
Synthesis of (–)-Strychnine

Synthesis of Heterocycles

z229
All PDFs of this category
229
Manganese-Catalyzed Ring Expansion of Cycloalkenes To Access Pyridines and Isoquinolines
230
Expanding Scope of Carbonylative Alkylative Amination
231
Ligand-Controlled Synthesis of Azepine Derivatives
232
Pd-Mediated Synthesis of Fused Azetidines/Oxetanes
233
Diastereoselectivity Switch in the Synthesis of Spirocyclic Pyrrolidine Derivatives
234
Electrochemically Mediated Synthesis of Cycloalkanes
235
Orthogonal Approach to Aminated Heterocyclic Derivatives
236
Visible-Light-Induced Radical Cyclization To Access Sulfamoylated Benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-ones
237
Base-Free Borylation of Aryl Bromides/Iodides Promoted by Zinc
238
Synthesis of Tetrahydroquinolines from N-Benzylhydroxylamines and Alkenes in HFIP Solvent
239
A Tandem Amination/Cyclization of Quinazolin-4(3H)-imines

Synthesis of Materials and Unnatural Products

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All PDFs of this category
241
Aromatic-Ring-Opening Metathesis
242
Boron-Facilitated N/C Atom Swapping in Triple Bonds
243
Benzo-2-azaboroles
244
Poly(p-phenylene iminoborane)
245
High MW Polyesters from Tishchenko Polymerizations
246
Stable Triplet Metallocarbenes
247
Stable High-Spin Hydrocarbon-Based Diradical
248
Enantioselective Synthesis of Helical Bilayer Nanographenes
249
Diameter-Controlled Growth of Single-Walled Carbon Nanotubes from Organic Nanobelts
250
Graphene-Like Covalent Organic Frameworks
251
Double-Hoop Cycloparaphenylene (CPP)
252
Decafluoroanthracene

Metals in Synthesis

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All PDFs of this category
253
Synthesis of Spirocyclic Oxaheterocycles via a Copper-Catalyzed Cyclization Alkene Transposition Sequence
254
Copper-Catalyzed Enantioselective Acyloxylation of Activated C(sp3)−H Bonds with Carboxylic Acids
255
Synthesis of Aza- and Oxoheterocycles from Alkenyl Amines and Alkenyl Alcohols under Palladium Catalysis
256
Stereodivergent Access to Glutamic Acid Derivatives under Pd/Cu Dual Catalysis
257
Rhodium-Catalyzed (Z)-Alkenyl Transfer to Aryl Ketones and Chalcones from Tertiary Allylic Alcohols
258
Accessing Asymmetric Spirooxindoles via Divergent [3+2] and [3+3] Cycloadditions on Cu-Allenylidenes
259
Remote Desaturation of Aliphatic Silyl Ethers under Dual Photoredox and Cobalt Catalysis
260
Enantioconvergent Difluoromethylation of α-Haloamides under Copper Catalysis
261
NiH-Catalyzed Polarity-Reversed Functionalization of Aliphatic Aldehydes
262
Difluoroalkylation of Alkenes via Visible-Light-Induced Palladium Catalysis
263
Switchable Site-Selective C(sp3)─H and C(sp2)─H Functionalization via Cp*CF3Ir(III) Catalysis
264
Copper-Catalyzed Synthesis of Naphthols from Enaminones and 1,3-Dicarbonyl Compounds
265
Synthesis of Fluorinated Bicyclo[4.1.1]octenes via (4+3) Annulation of BCBs and gem-Difluoroalkenes
266
Synthesis of Cyclopentanones with Contiguous All-Carbon Quaternary Stereocenters under Nickel Catalysis
267
Selective Alkylations and Alkenylations of Quaternary Ammonium Salts Using Photocatalysis
268
Asymmetric α-Alkylation of 2-Acylimidazoles by Copper(I) Catalysis
269
Use of Strained Vinyl BCBs in a [2σ+2π] Cycloaddition Catalyzed by Palladium
270
Site-Selective Hydrogenation of Amides Enabled by a Bifunctional Copper(I)/NHC–Guanidine Catalyst
271
[2+1] Enabled Skeletal Editing of N-Heterocycles
272
Making Dinitriles from Cyclic Ketones by a Copper-Catalyzed Aerobic Ammoxidation Reaction
273
Functionalization of Sulfonamides via a Multicomponent Cobalt-Catalyzed C–H Activation
274
Nickel-Catalyzed Asymmetric Intramolecular Hydroamidation of N-Alkenyl Formamides to γ-Lactams
275
Copper-Catalyzed Multicomponent Synthesis of Anilines
276
Photonitration of Arenes Using Iron(III) Nitrate as Nitrogen Dioxide Source
277
Double Nickel Migration Leads to the Synthesis of Silaindanes
278
Enantio- and Stereospecific Synthesis of β-Lactams via Ring Expansion of Aziridines under Rhodium Catalysis

Polymer-Supported Synthesis

z279
All PDFs of this category
279
Oxidative Cleavage of Alkenes Promoted by a COF-Supported Fe Complex under Photoirradiation
280
Synthesis of 4-Aryl-3-sulfonylquinolines through Radical Cascade Annulation Using a W2C Photocatalyst
281
Photocatalytic Coupling of N-Heteroarenes and Alkanes/Ethers with Ce-Doped g-C3N4 and Bu4NCl
282
Deoxygenative C2 Arylation of Quinoline N-Oxides with Phenylhydrazines Using Porous Tubular Graphitic C3N4
283
Cyclization of Homopropargylic Amines and CO2 Promoted by Cu Nanoparticles Supported on MOFs
284
Photo-Induced Oxidative Hydroxylation of Aryl Boronic Acids Using COF
285
Visible-Light-Switchable Oxidation of Benzyl Alcohols Using NiOOH Electrocatalyst
286
Synthesis of Isoindolones through C–H Activation and Annulation Using Pd/Cu Nanoparticles
287
Automated On-Resin Synthesis of Oligosaccharides Bearing a Phosphoethnolamine Unit
288
On-Resin Mukaiyama Oxidation–Reduction Thioesterification for Peptide Synthesis
289
α-Alkylation of Nitriles with a Nano Cobalt Catalyst Supported on a Porous N-Doped Carbon

Organo- and Biocatalysis

z291
All PDFs of this category
291
Unveiling and Engineering the Reverse Catalytic Potential of ‘Ene’-Reductases
292
A Benzo[ghi]perylene Monoimide Photocatalyst Defluorinates ‘Forever Chemicals’ under Visible Light
293
Intermolecular Electrocatalytic Cyclopropanation of Alkenyl Trifluoroborates with Methylene Compounds
294
Photocatalytic Reduction of Benzenes to Cyclohexenes
295
Oxidative Desymmetrization of meso-Diols via Photo and Base Catalysis
296
Asymmetric SET–NHC Catalysis in Three-Component Dicarbofunctionalizations
297
Enzymatic Enantioselective Radical Trifluoromethyl Azidation of Styrenes
298
Chiral-Isothiourea-Catalyzed [1,2]-Rearrangement of Ammonium Ylides
299
Catalytic Enantioselective Synthesis of 1,4-(Hetero) Dicarbonyl Compounds through α-Carbonyl Umpolung

Innovative Drug Discovery and Development

z301
All PDFs of this category
301
A Radical Approach to Secondary and Tertiary Amines
302
Metal-Free Amination of (Hetero)aryl Boronic Acids
303
Potassium Pivalate and Alcohol Cosolvents Enhance the Efficiency and Scalability of Miyaura Borylations
304
1,4-Metallate Migration Enables the Direct Synthesis of Organosulfates from Organoboron Compounds
305
Late-Stage E-to-Z Photoisomerization of Pharmaceuticals and Oligopeptides
306
Highly Efficient Conversion of Nitriles into Alcohols
307
Fluorine at the Forefront: Transforming Opioid Antagonism with C(20)-Modified Orvinols
308
Photochemical [4+2] Annulation of Silylimines to Access 1-Aminotetralins
309
Ruthenium-Catalyzed Carbocycle-Selective Asymmetric Hydrogenation of Fused N-Heteroarenes
310
(1R,3aS,4S)-Octahydro-1,4-methanopyrrolo[3,4-c]pyrrole, a Potential Piperazine or 4-Aminopiperidine Mimetic
311
Targeted Degradation of an ‘Undruggable’ Protein Scaffold to Treat Neuroblastoma
312
An Artificial Photoenzyme with a Thioxanthone Amino Acid Forms a Highly Strained Azetidine–Indole Scaffold
313
Synthesis of Eglumegad

Peptide Chemistry

z315
All PDFs of this category
315
Synthesis of β-Amino Acids from α-Amino Acids Using Visible-Light Photoredox Catalysis
316
Copper-Photoredox-Catalyzed Site-Selective Arylation and Alkylation of Glycine-Containing Peptides
317
TfOH-Mediated Late-Stage Functionalization of Tryptophan Peptide Residues
318
NHC-Catalyzed β-Keto Amino Acid Synthesis from Aldehydes and Imines
319
Copper-Catalyzed C(sp3)–H Benzylation at the α-Position of Glycine Derivatives
320
A New Coupling Reagent with No Heteroatomic Bonds for Amidation
321
Mn(OAc)3·2H2O-Mediated Phosphorylation of Dehydroamino Acids
322
A Liquid-Phase Peptide Synthesis (LPPS) Support for the Synthesis of Octreotide
323
Racemization-Free Visible-Light-Mediated Synthesis of Peptides
324
Synthesis of Unnatural Cyclic Peptides via Cu-Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides
325
Synthesis of Peptoids by a Flow Reaction Avoiding Undesired Diketopiperazine Formation
326
Accessing Photoswitchable Peptides by Embedding Spiropyrans in the Backbone of Peptides
327
A Facile Route to Accessing an Unusual Bicyclic Melanocortin-3 Receptor Antagonist: Compound 11
328
PTC-Catalyzed Asymmetric Alkylation of Glycine Imines for the Synthesis of Unnatural Amino Acid Esters

Flow Chemistry

z329
All PDFs of this category
329
Electrochemical C–O and C–N Arylation Using Alternating Polarity in Flow