Hutskalova V,
Sparr C *.
University of Basel, Switzerland
Aromatic Ring-Opening Metathesis.
Nature 2024;
DOI:
10.1038/s41586-024-08472-z
Keywords
aromatic ring-opening metathesis - ring-closing metathesis - cascade reactions - Schrock–Hoveyda molybdenum catalyst
Significance
Ring-opening metathesis with aromatic substrates is apparently more challenging than with alkenes due to the energy required for counteracting the stability conferred by aromaticity. Here, an innovative catalytic strategy is harnessed to realize the aromatic-ring-opening metathesis (ArROM) by coupling with aromatic-ring-closure processes.
Comment
The Schrock–Hoveyda molybdenum catalysts are demonstrated to enable efficient metathesis transformations with diverse aromatic hydrocarbons and heterocycles, including atroposelective and cascade ring-opening/ring-closure reactions.
