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Synlett
DOI: 10.1055/a-2529-5234
DOI: 10.1055/a-2529-5234
letter
A Novel Condensation–Cyclization Reaction of 4-Chloro-3-formylcoumarin with Amidoximes: Facile Synthesis of Coumarin-Fused Pyrimidinones
The Institute for Advanced Studies in Basic Sciences is thanked for partial supporting this work. This work was based upon research funded by the Iran National Science Foundation (INSF) under project no. 4038081.
Abstract
Coumarin-fused heterocyclic compounds are important materials with wide applications in biological and drug design. We report here a novel condensation–cyclization reaction of 4-chloro-3-formylcoumarin with amidoximes. The reaction gave a novel conjunction and hybrid compound of coumarin with pyrimidinones. Condensation–cyclization reactions of amidoximes with 4-chloro-3-formylcoumarin under catalyst-free conditions gave various coumarin derivatives of pyrimidinones in good to excellent yield.
Key words
coumarins - amidoximes - condensation–cyclization - pyrimidines - 4-chloro-3-formylcoumarinSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a- 2529-5234.
- Supporting Information
Publikationsverlauf
Eingereicht: 30. Dezember 2024
Angenommen nach Revision: 30. Januar 2025
Accepted Manuscript online:
30. Januar 2025
Artikel online veröffentlicht:
14. März 2025
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References and Notes
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