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Synfacts 2008(12): 1344-1344  
DOI: 10.1055/s-0028-1083559
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Huisgen 1,3-Dipolar Cycloaddition with an Ionic Polymer-Supported Copper(I) Catalyst

Contributor(s): Yasuhiro Uozumi, Yoshinori Hirai
U. Sirion, Y. J. Bae, B. S. Lee, D. Y. Chi*
Inha University, Inchon and FutureChem Co. Ltd., Seoul, Korea
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Publication History

Publication Date:
20 November 2008 (online)

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Significance

The ionic polymer-supported copper(I) (1) catalyzed the Huisgen 1,3-cycloaddition reaction of azides and terminal alkynes in t-BuOH-H2O to give the corresponding 1,4-disubstituted 1,2,3-triazoles in 36-99% yield (12 examples). In the reaction of 4-methoxybenzylazide and phenyl­acetylene, catalyst 1 was recovered by filtration and reused ten times without significant loss of catalytic activity (1st-10th runs: 100% conversions).